Evidence for sphincter dysfunction in patients with gallstone associated pancreatitis: Effect of ceruletide in patients undergoing cholecystectomy for gallbladder disease and gallstone associated pancreatitis

Author:

Cuschieri A1,Cumming J G R1,Wood R A B1,Baker P R1

Affiliation:

1. Department of Surgery, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK

Abstract

Abstract The functional activity of the sphincter of Oddi complex has been examined by ceruletide manometry in patients undergoing cholecystectomy with a normal peroperative cholangiogram. In Group I (n = 14), which included patients with previous acute cholecystitis/biliary colic, the sphincter activity appeared to be normal and responded to intravenous ceruletide by a marked relaxation with a significant fall in both the infusion and postinfusion pressures. In patients undergoing cholecystectomy for gallstone-associated pancreatitis (n = 8), the sphincter exhibited manometric features of hypotonia with low infusion and postinfusion pressures which were not significantly altered by intravenous ceruletide.

Publisher

Oxford University Press (OUP)

Subject

Surgery

Reference21 articles.

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2. Gallstone pancreatitis. Biliary tract pathology in relation to time of operation;Stone;Ann Surg,1981

3. Gallstone pancreatitis: the timing of surgery;Kelly;Surgery,1980

4. Early surgery for acute gallstone pancreatitis: evaluation of a systematic approach;Acosta;Surgery,1978

5. The etiology of acute haemorrhagic pancreatitis;Opie;Bull Johns Hopkins Hosp,1901

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