Severe complications of perianal sepsis in patients with human immunodeficiency virus

Author:

Consten E C J1,Slors J F M1,Danner S A2,Sars P R A1,Obertop H1,van Lanschot J J B1

Affiliation:

1. Department of Surgery, AIDS Unit, Academic Medical Centre, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands

2. Department of Internal Medicine, AIDS Unit, Academic Medical Centre, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands

Abstract

Abstract Fifty human immunodeficiency virus (HIV)-infected patients with perianal sepsis were studied. Seven (14 per cent) had serious septic complications, four patients with severe necrotizing gangrene, and three with abscesses in the mediastinum, liver and brain respectively. CD4 + lymphocyte counts were significantly lower in patients with severe septic complications as compared with those with uncomplicated perianal sepsis (P<0·05). In patients with HIV presenting with rare (metastatic) abscesses, perianal sepsis must always be kept in mind as a possible focus. Although HIV-infected patients have a limited life expectancy perianal fistulas and abscesses should be aggressively treated, because of the high risk of severe complications.

Publisher

Oxford University Press (OUP)

Subject

Surgery

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