Prognostic significance of lymph node dissection in gastric cancer

Author:

De Manzoni G1,Verlato G2,Guglielmi A1,Laterza E1,Genna M1,Cordiano C1

Affiliation:

1. First Department of General Surgery, University of Verona, Verona, Italy

2. Department of Medical Statistics, University of Verona, Verona, Italy

Abstract

Abstract The results for 162 patients who underwent curative gastrectomy for gastric cancer from January 1988 to June 1994 were analysed statistically with special reference to the effect of lymph node dissection. Median survival was 69·3 months and the overall cumulative 5-year survival rate was 50·2 (95 per cent confidence interval (c.i.) 41·6–58·1) per cent. By univariate analysis age, histology, depth of tumour invasion, node involvement, number of metastatic lymph nodes and type of lymphadenectomy were found to be significant factors related to survival time. Multivariate analysis with the Cox model and stratified for tumour node metastasis stage revealed that only the number of metastatic nodes (P = 0·04) and the extent of lymphadenectomy (P = 0·003) affected survival independently. With respect to D, lymphadenectomy, the relative risk associated with D2 and D4 lymphadenectomy was respectively 0·61 (95 per cent c.i. 0·34–1·10) and 0·26 (95 per cent c.i. 0·12–0·60). The 5-year survival rate was 28 per cent for patients who had a D1 dissection, 63 per cent for those who had D2 and 68 per cent for those who had D4. These results suggest that extended lymphadenectomy (D2) and especially superextended lymphadenectomy (D4) can improve survival in patients with gastric cancer.

Publisher

Oxford University Press (OUP)

Subject

Surgery

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3