Renal transplantation: The nonstarters

Author:

Lennard T W J1,Parrott N R1,Wilson R G1,Proud G1,Farndon J R1,Simpson Judy M2,Taylor R M R1

Affiliation:

1. Department of Surgery, The University of Newcastle upon Tyne, UK

2. Department of Medical Statistics, The University of Newcastle upon Tyne, UK

Abstract

Abstract Renal transplants do not always function immediately and this non-function may be related to poor long-term graft survival. The causes of this primary non-function (PNF) are poorly understood. The incidence of PNF in 106 consecutive renal transplants was found to be 57 per cent. Using stepwise logistic regression analysis of 20 prospectively collected variables for each transplant two have been found to be positively associated with PNF of the transplant: (1) the use of cyclosporin as an immunosuppressant and (2) a second warm ischaemia (anastomosis) time of more than 30 min. It is proposed that the use of cyclosporin be restricted in the early post-transplant period until initial function of the transplant is established. The surgical procedure of kidney transplantation should be planned to minimize the anastomosis time prior to recirculation of the graft.

Publisher

Oxford University Press (OUP)

Subject

Surgery

Reference22 articles.

1. Initial non-function of cyclosporine treated cadaver renal allografts preserved by simple cold storage;Belitsky;Transplant Proc,1985

2. The effects of delayed function on recipients of cadaver renal allografts: a study of 158 patients randomised to CyA or ALG-azathioprine;Canafax;Transplantation,1986

3. The impact of acute tubular necrosis on graft outcome in patients receiving cyclosporin;Carpenter;Transplant Proc,1985

4. Experience with CyA/prednisolone therapy in kidney transplantation with special reference to nephrotoxicity, acute tubular necrosis and kidney preservation;Pichlmayr;Neth J Med,1985

5. Should we be using kidneys from older donors?;Foster,1987

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