Superselective intra-arterial chemotherapy with mitomycin for gallbladder cancer

Author:

Mäkelä J T1,Kairaluoma M I1

Affiliation:

1. Department of Surgery, Division of Gastroenterology, University of Oulu, Kajaanintie 50, 90230 Oulu, Finland

Abstract

Abstract A group of 27 patients with carcinoma of the gallbladder was treated by superselective intra-arterial chemotherapy with mitomycin between 1981 and 1990. Results were compared with those in 22 historical controls. The overall response rate to intra-arterial chemotherapy was 48 per cent. The median survival time for responders was 34 months and for non-responders 8 months. Survival was significantly related to tumour stage in patients treated by chemotherapy (P < 0.001) and controls (P < 0.01); all patients with tumour extending beyond the serosa died within 4 years. The median survival period after intra-arterial chemotherapy was 14 months, compared with 4 months in controls. The cumulative 5-year survival rates for patients treated by chemotherapy and controls were not significantly different. Cessation of chemotherapy was required in 16 of the 27 patients: in eight because of tumour progression, in seven after toxicity to chemotherapy and in one because of patient refusal. Superselective intra-arterial chemotherapy can be useful for patients with cancer restricted to the gallbladder wall but cannot prevent tumour growth once this has extended beyond the gallbladder serosa.

Publisher

Oxford University Press (OUP)

Subject

Surgery

Reference34 articles.

1. Primary carcinoma of the gallbladder. Collective reviews;Piehler;Surg Gynecol Obstet,1978

2. Carcinoma of the gallbladder: a risk associated with gallbladder-preserving treatments for cholelithiasis;So;Radiology,1990

3. Primary carcinoma of the gallbladder;Nishino;Am Surg,1988

4. Aggressive surgery for carcinoma of the gallbladder;Nakamura;Surgery,1989

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