Affiliation:
1. University Department of Surgery, Welsh National School of Medicine
Abstract
Abstract
A double blind crossover trial of the prolactin inhibitor bromocriptine in painful benign breast disease is reported. Twenty-nine women with cyclical mastalgia and 11 with non-cyclical pain were treated with bromocriptine, 5 mg daily, and placebo over six menstrual cycles. Assessment of response to treatment was made by a linear analogue system and clinical examination together with plasma prolactin estimations. Bromocriptine produced a significant improvement in breast symptoms and a significant improvement in breast symptoms and a significant fall in prolactin levels in the cyclical pain group, but had no effect in the non-cyclical group. These results suggest that bromocriptine offers a new and effective approach in the management of cyclical breast pain.
Publisher
Oxford University Press (OUP)
Reference13 articles.
1. Measurement of feelings using visual analogue scales;Aitken;Proc. R. Soc. Med.,1969
2. Effect of bromocriptine on the premenstrual syndrome. A double blind clinical trial;Andersen;Br. J. Obstet. Gynaecol.,1977
3. The effect of endocrines on fibro-adenosis;Atkins;Br. Med. J.,1949
4. Fibroadenosis;Atkins;Br. J. Surg.,1950
5. Premenstrual tension and functional infertility–aetiology and treatment;Beneder-Jaszmann;Lancet,1976
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