The wound fibroblast and macrophage. I: Wound cell population changes observed in tissue culture

Author:

Stewart Richard J1,Duley John A1,Rosman Ingrid1,Fraser Robin1,Allardyce Randall A1

Affiliation:

1. Department of Surgery and Pathology, Christchurch Clinical School and Hospital, Christchurch 1, New Zealand

Abstract

Abstract The number and type of cells which migrated from sequential explants of wounded fascia in rats reflected the dense and changing cell populations observed in healing wounds. Macrophages appeared in large numbers from explants taken in the 5 days following injury, thereafter fibroblast-like cells predominated. The results support the hypothesis that the fibroblast-like cell of tissue culture is the same as the wound fibroblast. The technique can be used to obtain wound cells and provides a useful bridge between in vivo and in vitro means of investigating wound repair.

Publisher

Oxford University Press (OUP)

Subject

Surgery

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