Tissue factor expression correlates with histological grade in human pancreatic cancer-Reference-Cited by-同舟云学术

Tissue factor expression correlates with histological grade in human pancreatic cancer

Published:1995-08 Issue:8 Volume:82 Page:1101-1104
ISSN:0007-1323
Container-title:British Journal of Surgery
language:en
Short-container-title:

Author:

Kakkar A K¹,Lemoine N R²,Scully M F³,Tebbutt S¹,Williamson R C N¹

Affiliation:

1. Department of Surgery, London, UK

2. ICRF Oncology Unit, Royal Postgraduate Medical School, London, UK

3. Thrombosis Research Institute, London, UK

Abstract

Abstract The transmembrane cellular receptor tissue factor (TF) is the primary initiator of the coagulation cascade in man. Expression of TF was determined in 55 specimens of ductal adenocarcinoma of the pancreas and was found to correlate strongly with the degree of histological differentiation. A significant linear trend was observed with stronger immunoreactivity observed in poorly differentiated tumours (X2 = 6·69, P = 0·0098). No TF staining was seen in pancreatic samples from normal controls (n = 18). As expression of TF may be associated with tumour progression, its analysis could provide useful prognostic information in patients with pancreatic malignancy.

Funder

The special trustees of the Hammersmith and Queen Charlotte's Special Health Authority

Publisher

Oxford University Press (OUP)

Subject

Surgery

Link

http://academic.oup.com/bjs/article-pdf/82/8/1101/36814671/bjs1800820831.pdf

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