Role of fine-needle aspiration cytology and needle-core biopsy in the diagnosis of lobular carcinoma of the breast

Author:

Sadler G P1,McGee S2,Dallimore N S2,Monypenny I J2,Douglas-Jones A G3,Lyons K2,Horgan K1

Affiliation:

1. Department of Surgery, University of Wales College of Medicine, Cardiff, UK

2. Department of Breast Test Wales, University of Wales College of Medicine, Cardiff, UK

3. Department of Pathology, University of Wales College of Medicine, Cardiff, UK

Abstract

Abstract Fine-needle aspiration cytology (FNAC) plays a key role in the preoperative diagnosis of carcinoma of the breast but is less reliable in the diagnosis of infiltrating lobular carcinoma. The method of diagnosis was reviewed in 56 patients with lobular carcinoma who had attended screening and symptomatic clinics. In 29 patients FNAC results demonstrated malignant cells; 15 of these had palpable disease and the mean tumour size was 21 mm. In 27 patients FNAC failed to demonstrate malignant cells; 13 lesions were palpable and the mean tumour size was 23 mm. Ten patients were diagnosed by needle-core biopsy when FNAC was not diagnostic. FNAC may fail to diagnose even large lobular carcinoma and needle-core biopsy is strongly recommended in this situation.

Publisher

Oxford University Press (OUP)

Subject

Surgery

Reference8 articles.

1. Fine needle aspiration cytology in the diagnosis of primary breast cancer;Smith;Surgery,1988

2. Breast masses: US-guided fine-needle aspiration biopsy;Fornage;Radiology,1987

3. Cytologic diagnosis of occult breast lesions using stereotaxic needle aspiration. A preliminary report;Dowlatshahi;Arch Surg,1987

4. Preoperative diagnosis in breast cancer;Horgan;Br J Surg,1992

5. Invasive lobular carcinoma: mammographic findings in a 10-year experience;Hilleren;Radiology,1991

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