New concepts in the pathophysiology of oxygen metabolism during sepsis-Reference-Cited by-同舟云学术

New concepts in the pathophysiology of oxygen metabolism during sepsis

Published:1995-07 Issue:7 Volume:82 Page:870-876
ISSN:0007-1323
Container-title:British Journal of Surgery
language:en
Short-container-title:

Author:

Vlessis A A¹²,Goldman R K¹,Trunkey D D¹

Affiliation:

1. Department of Surgery, Oregon Health Sciences University, Portland, Oregon, USA

2. Departments of Biochemistry and Molecular Biology, Oregon Health Sciences University, Portland, Oregon, USA

Abstract

Abstract Sepsis is an intriguing pathological condition associated with many complex metabolic and physiological alterations. In this review a novel hypothesis in the pathophysiology of oxygen metabolism during sepsis is explored. It is proposed that the hypermetabolic response to sepsis results from enhanced reactive oxygen generation by phagocytes. Reactive oxygen detoxification by host enzyme systems subsequently leads to alterations in oxidative metabolism. The similarities between the metabolic consequences of reactive oxygen metabolism and the metabolic changes observed during sepsis are outlined. A unified concept is presented to help explain the pathophysiological changes in oxygen metabolism during sepsis.

Publisher

Oxford University Press (OUP)

Subject

Surgery

Link

http://academic.oup.com/bjs/article-pdf/82/7/870/36815355/bjs1800820705.pdf

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