The influence of tumour cell DNA abnormalities on survival in colorectal cancer-Reference-Cited by-同舟云学术

The influence of tumour cell DNA abnormalities on survival in colorectal cancer

Published:1985-10 Issue:10 Volume:72 Page:828-830
ISSN:0007-1323
Container-title:British Journal of Surgery
language:en
Short-container-title:

Author:

Armitage N C¹,Robins R A²,Evans D F¹,Turner D R³,Baldwin R W⁴,Hardcastle J D¹

Affiliation:

1. Department of Surgery, University Hospital, Nottingham

2. University of Nottingham, Nottingham

3. Department of Pathology, University Hospital, Nottingham

4. Cancer Research Campaign Laboratories, University Park, Nottingham

Abstract

Abstract The cellular DNA content was measured from paraffin-embedded material in 134 colorectal cancers from patients in whom the outcome was known. Seventy-two (55 per cent) were found to contain cells with abnormal DNA (DNA aneuploid). The presence of such a population of cells was not related to pathological stage or histological grade. However, only 14 (19 per cent) patients with DNA aneuploid tumours survived 5 years compared with 27 (43 per cent) of patients with diploid tumours (χ2 = 8·0, P = 0·005). Stepwise logistic analysis showed cellular DNA content to be an important prognostic factor in colorectal cancer, independent of pathological stage and histological grade.

Funder

Cancer Research Campaign

Publisher

Oxford University Press (OUP)

Subject

Surgery

Link

http://academic.oup.com/bjs/article-pdf/72/10/828/36915256/bjs1800721018.pdf

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