Experimental fat embolism: A dynamic assessment of pulmonary fat-handling characteristics

Abstract

Abstract Injection 125I-glyceryl trioleate (0.5 mg/kg) into the right atrium of anaesthetized greyhounds caused the following changes: sequestration of fat in the right side of the heart; 95 per cent removal by the lungs in a single passage through the pulmonary circulation; subsequent release of fat into the systemic circulation; rapid overall turnover of fat trapped in the lungs and slow removal of recirculating fat by other tissues. We believe that if there is release of unemulsified fat into the circulation in traumatic fat embolism these findings are of significance in interpreting the subsequent pulmonary events.