Value of oral antibiotic prophylaxis in colorectal surgery-Reference-Cited by-同舟云学术

Value of oral antibiotic prophylaxis in colorectal surgery

Published:1995-08 Issue:8 Volume:82 Page:1046-1048
ISSN:0007-1323
Container-title:British Journal of Surgery
language:en
Short-container-title:

Author:

McArdle C S¹,Morran C G²,Pettit L¹,Gemmell C G³,Sleigh J D³,Tillotson G S⁴

Affiliation:

1. University Department of Surgery, Royal Infirmary, Glasgow, UK

2. Crosshouse Hospital, Kilmarnock, Ayrshire, UK

3. Department of Bacteriology, Royal Infirmary, Glasgow, UK

4. Bayer (UK) Ltd, Newbury, UK

Abstract

Abstract A total of 169 patients undergoing colorectal surgery were randomly allocated to receive either gentamicin plus metronidazole or oral ciprofloxacin plus metronidazole as prophylaxis; they were also allocated to receive cover for 1 or 3 days. Twenty-eight patients (17 per cent) developed postoperative wound infections. The proportion of patients with wound infections and other infective complications was significantly less (P < 0·02) in those receiving oral ciprofloxacin. Cover for 3 days was no better than that for only 1 day. Oral ciprofloxacin for prophylaxis may offer advantages in efficacy and ease of administration compared with parenteral antibiotics.

Publisher

Oxford University Press (OUP)

Subject

Surgery

Link

http://academic.oup.com/bjs/article-pdf/82/8/1046/36815017/bjs1800820814.pdf

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