Affiliation:
1. Departments of Surgery and Pharmacology, Charing Cross Hospital Medical School, London
Abstract
Summary
Two inhibitory mechanisms in the human colon which may contribute to postoperative ileus have been studied.
Dopamine, a possible peripheral neurotransmitter, inhibited isolated colonic smooth muscle strips by a direct effect in longitudinal muscle and by a nerve-mediated mechanism in circular muscle.
Plasma motilin levels were suppressed pre- and peroperatively and elevation of levels postoperatively correlated with the return of normal motility and the severity of the operation.
Publisher
Oxford University Press (OUP)
Reference22 articles.
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3. Ileus: the restoration of alimentary tract motility by pharmacological means;Neely;Br. J. Surg.,1971
4. Selective damage to cholinergic nerves; possible cause of postoperative ileus;Davison;Lancet,1979
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