The experimental production of gastric ulcers by induced muscle spasm

Abstract

Abstract A new technique is described for the experimental production of gastric ulcers in dogs. It depends on producing an intermittent but severe localized increase in the contractility of the stomach by means of electrodes implanted in the gastric muscle. A suitable stimulator is attached to the animal's back. Following some early technical, failures an adequate stimulus was applied for 2–3 weeks in 16 animals. In 13 cases macroscopic lesions developed in the stimulated area, varying from frank perforation to superficial erosions. Confirmation by barium meal examinations and histology is provided. It is suggested that the responsible mechanism may be a localized ischaemia, due to the increased muscle spasm, predisposing to the necrosis and ulceration of the mucosa followed by the more superficial layers of the stomach wall.