Affiliation:
1. Department of Surgery, The University of Chicago, Chicago, Illinois, U. S. A.
Abstract
Abstract
The lower oesophageal high pressure zone (HPZ) was studied in 5 non-refluxing and 3 refluxing Rhesus monkeys. The changes in HPZ and reflux status in response to infusion of various doses of secretin, cholecystokinin and glucagon were measured in all animals, and, in the 5 non-refluxing monkeys, after oesophagogastrectomy with replacement of the lower oesophagus by a stomach tube. All three hormones consistently produced a transient decrease in the HPZ pressure. The only change in response following oesophagogastrectomy and gastric tube replacement was a significant delay in the response to each hormone. Neither hormone infusion nor operation altered gastro-oesophageal reflux status.
It appears that lower oesophageal competence in primates is more dependent on the presence of a narrow, muscular, intra-abdominal tube than on a specialized segment of the lower oesophagus.
Publisher
Oxford University Press (OUP)
Cited by
12 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献