Tumour oestrogen receptor content allows selection of elderly patients with breast cancer for conservative tamoxifen treatment-Reference-Cited by-同舟云学术

Tumour oestrogen receptor content allows selection of elderly patients with breast cancer for conservative tamoxifen treatment

Published:1992-12 Issue:12 Volume:79 Page:1314-1316
ISSN:0007-1323
Container-title:British Journal of Surgery
language:en
Short-container-title:

Author:

Low S C¹,Dixon A R¹,Bell J²,Ellis I O²,Elston C W²,Robertson J F R¹,Blarney R W¹

Affiliation:

1. Professorial Unit of Surgery City Hospital, Hucknall Road, Nottingham NG5 1PB, UK

2. Department of Pathology, City Hospital, Hucknall Road, Nottingham NG5 1PB, UK

Abstract

Abstract Immunocytochemical analysis was used to determine tumour oestrogen receptor (ER) content in elderly patients with primary operable breast cancer. Only those ER positive were selected for conservative treatment with tamoxifen alone. Initial response was compared with that of historical controls not selected according to ER status. Early progressive disease was markedly reduced at 6 months, from 30 per cent in the unselected control group to 2 per cent in the study group (P < 0.001). Immunocytochemical analysis is useful for the initial selection of elderly patients with breast cancer who may be treated with tamoxifen alone.

Publisher

Oxford University Press (OUP)

Subject

Surgery

Link

http://academic.oup.com/bjs/article-pdf/79/12/1314/37129786/bjs1800791224.pdf

Reference14 articles.

1. Tamoxifen as initial sole treatment of localised breast cancer in elderly women: a pilot study;Preece;BMJ,1982

2. Primary treatment of breast cancer in elderly women with tamoxifen;Bradbeer;Clin Oncol,1983

3. Tamoxifen as an alternative to surgical resection for selected geriatric patients with primary breast cancer;Margolese;Arch Surg,1989

4. Long-term follow-up of elderly patients with locoregional breast cancer treated with tamoxifen only;Horobin;Br J Surg,1991

5. Prospective randomised trial of tamoxifen versus surgery in elderly patients with breast cancer;Gazet;Lancet,1988

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