Affiliation:
1. Department of Surgery, Charing Cross Hospital, London W6 8RF, UK
Abstract
Abstract
An in vivo method of measuring thrombus deposition and pseudo-intimal thickening in prosthetic arterial grafts in an animal model is described. The effect of indobufen, a new cyclo-oxygenase inhibitor, was evaluated and compared to aspirin plus dipyridamole and placebo in 24 greyhounds. Luminal platelet accumulation expressed as thrombogenicity index was 0.33 ± 0.07 in the placebo group. This was significantly reduced to 0.14 ± 0.01 by indobufen (P<0.05). The reduction to 0.19 ± 0.04 by aspirin plus dipyridamole failed to achieve statistical significance. Pseudointimal thickness when measured 28 days after implacement was significantly reduced to 21.4 ± 10.6 per cent by indobufen (P<0.01) and 29.4 ± 10.6 per cent by aspirin plus dipyridamole (P< 0.02) compared to 75 ± 10 per cent found in the placebo group. This prosthetic graft model has considerable advantages in the evaluation of potential platelet inhibitory drugs for use in vascular surgery.
Publisher
Oxford University Press (OUP)
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