Affiliation:
1. Department of Surgery, University of Newcastle-upon-Tyne
Abstract
Summary
Blood transfusions given to potential renal transplant recipients are beneficial to subsequent graft survival. This study has shown an association between the inhibitory activity of patients' plasma on their own non-specific lymphocyte responses to antigen and the administration of blood transfusions. Most of the inhibitory activity was related to alpha-2 macroglobulin. Alpha-2 macroglobulin was able to prolong the survival of rat cardiac allografts. Immunoregulatory activity related to the alpha globulins of plasma has been described in a wide variety of conditions (i.e. cancer, pregnancy, diabetes) and this study has shown similar activity following blood transfusions.
Publisher
Oxford University Press (OUP)
Reference29 articles.
1. Survival data of renal transplantations in patients;Barnes;Transplantation,1965
2. Separation of leucocytes from blood and bone marrow;Bøyum;Scand. J. Clin. Lab. Invest.,1968
3. Humoral immunosuppressive factors;Cooperband;Transplant. Proc.,1976
4. Immunodepressive serum treatment of acute heart transplant rejection;Coulson;Br. Med. J.,1976
5. Do plasma glycoproteins induce lymphocyte hyporesponsiveness and insulin resistance?;Davis;Lancet,1978
Cited by
29 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献