Prediction and prophylaxis of postoperative thromboembolis—a comparison between peroperative calf muscle stimulation with groups of impulses and dextran 40

Author:

Lindström B1,Holmdahl C1,Jonsson O1,Korsan-Bengtsen K1,Lindberg S1,Petrusson B1,Pettersson S1,Wikstrand J1,Wojciechowski J1

Affiliation:

1. Departments of Oto-rhino-laryngology, Surgery I, Nuclear Medicine, Urology, Internal Medicine II, Radiology and Clinical Physiology, University of Göteborg, Göteborg, Sweden

Abstract

Abstract The effects of peroperative electrical calf muscle stimulation with groups of impulses giving a short lasting tetanus of the calf muscles on postoperative deep venous thrombosis (DVT) and pulmonary embolism (PE) were compared with that of dextran 40 given perand postoperatively. The incidence of DVT and PE during the first 4–6 postoperative days was recorded. The diagnosis of DVT was based on the 125I-fibrinogen uptake test and phlebography and of PE on pre- and postoperative perfusion pulmonary scintigram and chest X-ray examination. Both methods reduced the incidence of PE. Calf muscle stimulation reduced the DVT incidence in patients with malignant disease while the reduction in DVT incidence for the whole group only was significant in the stimulation as well as the dextran 40 group. Mean values for preoperatively determined levels of antithrombin III, beta-thromboglobulin, fibrinopeptide A, plasminogen and ability to release fibrinolytic activity during venous stasis did not differ between those patients who developed or those who did not develop postoperative DVT or PE. However, antithrombin III levels below 80 per cent appeared to predispose to postoperative thromboembolism. The two prophylactic methods have similar effects on the incidence of postoperative thromboembolism. The stimulation method has certain advantages due to its safety and simplicity.

Publisher

Oxford University Press (OUP)

Subject

Surgery

Reference37 articles.

1. Prophylaxis of postoperative venous thrombosis in a controlled trial comparing Dextran 70 and low dose heparin;Bergqvist;World J. Surg.,1980

2. Prevention of fatal postoperative pulmonary embolism by low doses of heparin;An International Multi centre Trial;Lancet,1975

3. The detection of venous thrombosis of the legs using 125I-labelled fibrinogen;Flanc;Br. J. Surg.,1968

4. A simple way to combat the venous stasis which occurs in the lower limbs during surgical operations;Doran;Br. J. Surg.,1964

5. Optimal electrical stimulus for prevention of deep vein thrombosis;Nicolaides;Br. Med. J.,1972

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