An evaluation of kidney preservation techniques

Author:

McLoughlin Gerard A1,Sells Robert A1,Tyrrell Irene1

Affiliation:

1. Department of Surgery, University of Liverpool

Abstract

Abstract Experimental evidence is presented showing that progressive renal ischaemic damage results in an increase in intracellular water with eventual production of the ‘no reflow’ phenomenon. Preservation techniques have been compared in their ability to resist intracellular water gain. A colloidal perfusate with low lipid content and a potassium concentration of greater than 15 mEqll was the most effective preservation medium tested.

Publisher

Oxford University Press (OUP)

Subject

Surgery

Reference27 articles.

1. Ionic and histological changes in the kidney after perfusion and storage for transplantation;Aquatella;Transplantation,1972

2. 24-hour and 72-hour preservation of canine kidneys;Belzer;Lancet,1967

3. Kidney preservation for transportation. Initial perfusion and 30 hours’ ice storage;Collins;Lancet,1969

4. An in vitro method for determination of the inulin space of skeletal muscle with observation on the composition of human muscle;Flear;Clin. Sci.,1960

5. The role of cell swelling in ischaemic renal damage and the protective effect of hypertonic solute;Flores;J. Clin. Invest.,1972

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