Affiliation:
1. Department of Surgery 1, Kyushu University Faculty of Medicine, Fukuoka 812, Japan
Abstract
Abstract
The relationship between hepatic DNA synthetic rate and activity of cholesterol 7α-hydroxylase, the rate limiting enzyme for bile acid synthesis, was examined in regenerating liver after partial hepatectomy or sham operation in rats. Hepatic cholesterol 7α-hydroxylase activity was significantly (P < 0·001) suppressed on days 1 and 2, returned to the control level on day 3, and was significantly raised on day 7 after hepatectomy. The rate of DNA synthesis was significantly (P < 0·001) activated during the first 3 days after hepatectomy and returned to the control level on day 7. Enzyme activities regulating hepatic bile acid synthesis and DNA synthesis change inversely during liver regeneration after hepatectomy.
Funder
Ministry of Education, Japan for Dr Chijiiwa
Publisher
Oxford University Press (OUP)
Reference23 articles.
1. Rat liver regeneration after 90% partial hepatectomy;Gaub;Hepatology,1984
2. Regeneration of human liver after major hepatectomy;Pack;Surgery,1962
3. Human liver regeneration after major hepatectomy. A study of liver volume by computed tomography;Chen;Ann Surg,1991
4. Proliferating cell nuclear antigen, plasma fibronectin, and liver regeneration rate after seventy percent hepatectomy in normal and cirrhotic rats;Chijiiwa;Surgery,1994
5. Secretion of biliary lipids from the hepatocyte;Marzolo;Hepatology,1990
Cited by
6 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献