Accurate method to measure the percentage hepatic replacement by tumour and its use in prognosis of patients with advanced colorectal cancer

Author:

Purkiss S F1,Williams N S1

Affiliation:

1. Surgical Unit, The Royal London Hospital, Whitechapel, London E1 1BB, UK

Abstract

Abstract The natural history of patients with colorectal hepatic metastases was studied following resection of the primary tumour. Patients were stratified according to the presence of extrahepatic disease and the percentage hepatic replacement (PHR) measured by planimetry of computed tomographic images. The median(semi-interquartile range (s.i.r.)) PHR of patients without extrahepatic disease was 15.0(10.5) and for those with extrahepatic disease 5.4(2.2) (P < 0.02). The median(s.i.r) PHR of all patients was 8.7(8.5). The median(s.i.r.) survival of all patients was 125(85.5) days, 92(114) days for patients with extrahepatic disease and 175(133.5) days for patients with disease confined to the liver (P < 0.02). A linear correlation between the natural logarithm of PHR and survival was demonstrated (ρ = −0.76, P < 0.001) for patients without extrahepatic disease. Extrahepatic disease in patients with colorectal hepatic metastases is a major determinant of survival; PHR has a direct association when extrahepatic disease is absent.

Publisher

Oxford University Press (OUP)

Subject

Surgery

Reference14 articles.

1. A retrospective study of the natural history of patients with liver metastases from colorectal cancer;Wood;Clin Oncol,1976

2. Factors influencing survival in patients with untreated hepatic metastases;Jaffe;Surg Gynecol Obstet,1968

3. Factors affecting survival in patients presenting with synchronous hepatic metastases from colorectal cancer: a clinical and computer analysis;Finan;Br J Surg,1985

4. A comparison of methods to measure the percentage hepatic replacement with colorectal liver metastases;Hunt;Ann R Coll Surg Engl,1989

5. Regional infusion chemotherapy of hepatic metastases from carcinoma of the colon;Cady;Am J Surg,1974

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