Affiliation:
1. Department of Surgery, University of Wales College of Medicine, Heath Park, Cardiff CF4 4XN, South Glamorgan, UK
Abstract
Abstract
Excess dietary fat has been identified as a risk factor in the development of human breast carcinoma. However, the quality of fat may be more important than the overall quantity. We have studied the growth of human MCF7 breast carcinoma xenografts in athymic mice treated with dietary supplements of N-6 and N-3 series essential fatty acids given as natural preparations of evening primrose oil and fish oil. Olive oil and normal laboratory diet lacking the essential fatty acids served as controls. Animals treated with essential fatty acids developed tumours which were significantly smaller than both control groups (Mann-Whitney U test, P<0.001). Median tumour weights according to diet were: evening primrose oil, 133 mg; fish oil, 70 mg; olive oil, 212 mg; and control, 270 mg. Nutritional intervention to increase the proportion of essential fatty acids in the diet may have a role in the management of breast carcinoma.
Publisher
Oxford University Press (OUP)
Reference42 articles.
1. Environmental factors and cancer incidence and mortality in different countries, with special reference to dietary practices;Armstrong;Int J Cancer,1975
2. The genesis and growth of tumours. III. Effect of a high fat diet;Tannenbaum;Cancer Res,1942
3. Effects of dietary fat and dose level of 7,12-dimethylbenz-(α)anthracene on mammary tumour incidence in rats;Carroll;Cancer Res,1970
4. Influence of dietary fatty acids on the incidence of mammary tumours in the C3H mouse;Tinsley;Cancer Res,1981
5. Influence of dietary fat on the induction of mammary tumours by N-nitrosomethylurea: associated hormone changes and differences between Sprague-Dawley and F344 rats;Chan;J Natl Cancer Inst,1977
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