Affiliation:
1. Department of Radiology Peking University First Hospital Beijing China
2. School of Basic Medical Sciences Capital Medical University Beijing China
Abstract
AbstractObjectivesTo develop radiomics models based on automatic segmentation of the pretreatment apparent diffusion coefficient (ADC) maps for predicting the biochemical recurrence (BCR) of advanced prostate cancer (PCa).MethodsA total of 100 cases with pathologically confirmed PCa were retrospectively included in this study. These cases were randomly divided into training (n = 70) and test (n = 30) datasets. Two predictive models were constructed based on the combination of age, prostate specific antigen (PSA) level, Gleason score, and clinical staging before therapy and the prostate area (Model_1) or PCa area (Model_2). Another two predictive models were constructed based on only prostate area (Model_3) or PCa area (Model_4). The area under the receiver operating characteristic curve (ROC AUC) and precision‐recall (PR) curve analysis were used to analyze the models’ performance.ResultsSixty‐five patients without BCR (BCR−) and 35 patients with BCR (BCR+) were confirmed. The age, PSA, volume, diameter and ADC value of the prostate and PCa were not significantly different between the BCR− and BCR+ groups or between the training and test datasets (all p > 0.05). The AUCs were 0.637 (95% CI: 0.434–0.838), 0.841 (95% CI: 0.695–0.940), 0.840 (95% CI: 0.698–0.983), and 0.808 (95% CI: 0.627–0.988) for Model_1 to Model_4 in the test dataset without significant difference. The 95% bootstrap confidence intervals for the areas under the PR curve of the four models were not statistically different.ConclusionThe radiomics models based on automatically segmented prostate and PCa areas on the pretreatment ADC maps developed in our study can be promising in predicting BCR of advanced PCa.
Subject
Radiology, Nuclear Medicine and imaging,Instrumentation,Radiation