Affiliation:
1. Institute for Tropical Technology Vietnam Academy of Science and Technology 18 Hoang Quoc Viet, Cau Giay Hanoi 100000 Vietnam
2. Graduate University of Science and Technology Vietnam Academy of Science and Technology 18 Hoang Quoc Viet, Cau Giay Hanoi 100000 Vietnam
3. Department of Chemical Technology Hanoi University of Industry 298 Cau Dien, Bac Tu Liem Hanoi 100000 Vietnam
4. Institute of Environmental Sciences Nguyen Tat Thanh University Ho Chi Minh City 700000 Vietnam
Abstract
AbstractThis study focused on 3D printing‐preparation of novel biomaterials based on fish scale collagen and the following plant extracts: Eclipta alba L. Hassk leaf (EA), Piper betle L. leaf (PB), Perilla frutescens L. Britt leaf (PF), and Styphnolobium japonicum L. Schott flower bud (SJ). The characterizations of the obtained biomaterials were analyzed using infrared spectroscopy and stereo microscopy. Additionally, assessments of the biomaterials were conducted on the water contact angle, simulated body fluid contact angle, scratch resistance, color changes, and swelling degree in simulated body fluid. Furthermore, in‐vitro blood clotting time and the anti‐inflammatory ability of these biomaterials were also performed. The results indicated that the plant extracts contributed to modifying collagen, significantly improving the scratch resistance and water contact angle of the collagen/plant extract biomaterials. The plant extracts were dispersed consistently with the collagen matrix, impacting the vibrations of specific functional groups of collagen. Collagen/plant extract dressings exhibited great biocompatibility and anti‐inflammatory. The in‐vitro tests demonstrated that the ethanol EA extract notably enhanced the hemostatic effectiveness of collagen, suggesting the potential of collagen/plant extract biomaterials in hemostatic applications.
Funder
Quỹ Đổi mới sáng tạo Vingroup