A Complete Study of Synthesis of Glycoluril and Its Derivative by Using Different Greener Acids

Abstract

AbstractThe synthesis of glycoluril and its derivatives is carried out using the greener acids. We have screened four different greener acids for this synthesis, namely, (1) ethan‐1,2‐diyl bis(hydrogen sulfate) (EDSA), (2) NMP‐HSO4 ionic liquids (NHIL), (3) choline chloride: p‐TSA( ChCl:p‐TSA) DES and (4) choline chloride: oxalic acid (ChCl:OA) DES. These acids are easy to make, safe to handle, environmentally benign and recyclable. Along with the glycoluril, different glycoluril derivatives are also prepared. We have also developed a novel glycoluril derivative in which we have introduced 4‐bromophenyl moieties at 2nd and 6th position of the glycoluril. Our developed method is a one‐step reaction with shorter reaction time and high product yield. All the acids are recyclable up to four cycles without considerable loss of the yield. A comparative study of the yield obtained with the four acids is also carried out.