Solvent‐Free Choline Derivative Synthesis as a Powerful Organic Synthesis Medium

Abstract

AbstractThis study synthesized choline amide as a solvent‐free reagent and ion liquid in one pot to directly create benzylamine without producing associated salts. The synthesis of benzyl azide was also carried out with choline azide solventless, and 1,2,3‐triazole was prepared in the method mentioned. The synthesis of 1,2,3‐triazoles followed the process of a formal benzyl azide cycloaddition. For this purpose, a deep eutectic solvent was used as a catalyst to complete the nitrostyrene process. Both reactions were conducted with a high isolated yield without harmful solvents or catalysts. Eco‐friendly and economically feasible, the method also met environmental standards.