Recent Advances in the Multicomponent Synthesis of Heterocycles using Thiosemicarbazide

Author:

Javahershenas Ramin1ORCID,Han Jianlin2ORCID,Kazemi Mosstafa3ORCID,Jervis Peter J.4ORCID

Affiliation:

1. Department of Organic Chemistry Faculty of Chemistry Urmia University Urmia Iran

2. Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources College of Chemical Engineering Forestry University 210037 Nanjing China

3. Young Researchers and Elite Club Islamic Azad University Tehran Branch Tehran Iran

4. Center of Chemistry University of Minho Campus de Gualtar 4710-057 Braga Portugal

Abstract

AbstractThis review provides an overview of the recent advances in the synthesis of diverse heterocyclic compounds using thiosemicarbazide as a key building block via multicomponent reactions. Thiosemicarbazide is a versatile reagent that has gained significant attention in organic synthesis due to its ability to participate in diverse multicomponent reactions for the efficient and sustainable construction and assembly of novel bioactive molecules and pharmaceuticals. This review discusses the potential applications and future directions in this rapidly evolving area of research. It provides valuable insights into the innovative approaches for the synthesis of heterocycles using thiosemicarbazide, showcasing its significance in modern organic chemistry research. In summary, this review provides an overview of the current state of the art, highlighting the use of thiosemicarbazide in the synthesis of novel heterocyclic compounds reported between 2015 and early 2024.

Publisher

Wiley

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