Ruthenium‐Catalyzed Synthesis of Macrocyclic Isoquinolines and Isoquinolones via a C−H/N−H Annulations Reaction-Reference-Cited by-同舟云学术

Ruthenium‐Catalyzed Synthesis of Macrocyclic Isoquinolines and Isoquinolones via a C−H/N−H Annulations Reaction

Published:2023-08-23 Issue:32 Volume:8 Page:
ISSN:2365-6549
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language:en
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Author:

Gurumurthy Palanivelu¹,Raja Rajini¹,Arumugam Natarajan²,Almansour Abdulrahman I.²,Kumar Raju Suresh²,Perumal Karthikeyan³,Parthasarathy Kanniyappan¹^ORCID

Affiliation:

1. Department of Organic Chemistry University of Madras Guindy Campus Tamilnadu Chennai 025 India

2. Department of Chemistry College of Science King Saud University P.O. Box 2455 Riyadh 11451 Saudi Arabia

3. Department of Chemistry and Biochemistry The Ohio State University, 151 W. Woodruff Ave Columbus OH 43210 USA

Abstract

AbstractAn Ru(II)‐catalyzed C−H annulations of oximes and N‐methoxybenzamides with bridged alkyne is described. This method is useful for the efficient synthesis of various macrocyclic isoquinolines and isoquinolones in good to moderate yields. A possible mechanism, involving a key five‐membered metallacycle intermediate, alkyne insertion followed by reductive elimination to give a final annulated product has been proposed.

Funder

King Saud University

Publisher

Wiley

Subject

General Chemistry

Reference86 articles.

2. R. Alajar_n C. Burgos in:Modern Heterocyclic Chemistry Vol. 3 (Eds.: J. Builla J. J. Vaquero J. Barluenga) Wiley-VCH Weinheim 2011 pp 1527–1629;

3. Reactivity of the human internal thoracic artery to vasodilators in coronary artery bypass grafting

4. T. Eicher S. Hauptmann The Chemistry of Heterocycles 2nd edn. Wiley-VCH Weinheim 2003;

5. Peripheral benzodiazepine receptors: on mice and human brain imaging