Affiliation:
1. Departamento de Química Facultad de Ciencias Universidad Nacional de Colombia Sede Bogotá, Carrera 30 No. 45-03 Bogotá Colombia
Abstract
AbstractThis work involved synthesizing three N‐benzyl‐4‐hydroxybenzylamines using indirect reductive amination of aromatic aldehydes and 4‐hydroxybenzylamine. Such benzylamines’ reaction with formaldehyde produced tricyclic azacyclophanes formed by two benzylamine units joined by methylene bridges. Computational calculations established that macrocyclization was promoted by template formation stabilized by hydrogen bonds and π‐stacking.