Affiliation:
1. School of Chemical Engineering Hanoi University of Science and Technology N01 Dai Co Viet, Hai Ba Trung Hanoi Vietnam
2. Institute of Biotechnology and Food Technology Hanoi University of Science and Technology N01 Dai Co Viet, Hai Ba Trung Hanoi Vietnam
3. School of Mechanical Engineering Kyungpook National University 80 Daehakro, Buk-gu Daegu 41566 Republic of Korea
Abstract
AbstractIn this research, the vorinostat‐loaded alginate microparticles were created and their characterization was performed using scanning electron microscopy (SEM), energy‐dispersive X‐ray mapping (EDX‐mapping), and transmission electron microscopy (TEM). Differential scanning calorimetry (DSC) was used to assess the drug state and thermal behavior of vorinostat within the microparticles. The encapsulation efficiency and loading efficiency were determined, and the solubility of vorinostat in the microparticles was investigated. In vitro drug release studies demonstrated sustained release of vorinostat from the microparticles. The cytotoxicity of vorinostat‐loaded alginate microparticles was evaluated using HepG2, MCF‐7, and SK‐LU‐1 cell lines. The results indicated significant inhibition of cell growth, and the IC50 values were estimated. Overall, this study successfully demonstrated the fabrication of vorinostat‐loaded alginate microparticles using a microfluidic approach, suggesting a simple and effective delivery system for vorinostat with improved physicochemical and pharmacological properties.