Affiliation:
1. School of Chemistry and Chemical Engineering Key Laboratory of Surface & Interface Science of Polymer Materials of Zhejiang Province Zhejiang Sci-Tech University Xiasha West Higher Education District, Hangzhou 310018 China
Abstract
AbstractA rhodium‐catalyzed cascade migration‐annulation reaction of 1‐sulfonyl‐1,2,3‐triazole has been developed. As the key step, the 1,3‐sulfinate migration of α‐imino rhodium carbene yielded an extended zwitterion, which was intramolecularly trapped by aldehyde group furnishing bridged N,O‐heterocyclic 1,6‐epoxybenzo[c]azocine as the [5+2] cyclization product. This migration‐annulation strategy provides more flexibility for heterocycle synthesis and medium‐sized ring construction, especially for the construction of polycycles with complex skeletons.
Funder
National Natural Science Foundation of China
Natural Science Foundation of Zhejiang Province