Affiliation:
1. School of Graduate Studies Department of Chemistry Çanakkale Onsekiz Mart University Çanakkale Türkiye
2. Laboratory of Inorganic Materials Department of Chemistry Faculty of Science Çanakkale Onsekiz Mart University Çanakkale Türkiye
Abstract
AbstractIn this study, p(CTP‐co‐MMCA) microparticles, a novel cyclomatrix polyphosphazene, were synthesized. Among the p(CTP‐co‐MMCA) polymeric structures, p(CTP‐co‐MMCA) (1 : 3) with a high surface amine group was found to be in the form of microparticles after detailed structural and morphological characterization. These microparticles were modified with Au0 and Ag0 nanoparticles using two different green reductants. The antimicrobial activities of p(CTP‐co‐MMCA) microparticles and their Au0 and Ag0 composites against P.Aeruginosa ATCC 27853, S.Aureus ATCC 6538 and C.Albicans were investigated. Metal composites were found to have better antimicrobial activity. Cyclomatrix p(CTP‐co‐MMCA) microparticles with antimicrobial properties and their Au0 and Ag0 composites were also used for the release of Ceftriaxone sodium and RNA. Cyclomatrix p(CTP‐co‐MMCA) microparticles and its Au0 and Ag0 composites retained 48.21±5.34 mg/g, 49.36±6.95 mg/g and 23.95±6.45 mg/g ceftriaxone sodium, respectively, while they retained 79.15±6.85 mg/g, 47.49±6.24 mg/g and 57.47±9.48 mg/g RNA, respectively. Release studies revealed that the presence of Au0 and Ag0 nanoparticles imparted a slower release behavior to p(CTP‐co‐MMCA) microparticles. The release studies revealed that the presence of Au0 and Ag0 nanoparticles imparted a slower release behavior to the p(CTP‐co‐MMCA) microparticles.