Investigation of Antimicrobial, Cytotoxic, and Larvicidal Activities of Favipiravir-Reference-Cited by-同舟云学术

Investigation of Antimicrobial, Cytotoxic, and Larvicidal Activities of Favipiravir

Published:2023-11-08 Issue:42 Volume:8 Page:
ISSN:2365-6549
Container-title:ChemistrySelect
language:en
Short-container-title:ChemistrySelect

Author:

Aydın Hasan¹²^ORCID,Uslu Uğur³^ORCID,Akocak Süleyman⁴^ORCID,Lolak Nebih⁴^ORCID,Sait Ahmet⁵^ORCID,Korkmaz Serol⁵^ORCID,Parmaksız Ayşe⁵^ORCID,Ceylan Onur⁶^ORCID,Aksakal Abdulbaki⁷^ORCID

Affiliation:

1. Department of Pharmaceutical Toxicology Faculty of Pharmacy Adıyaman University Adıyaman Türkiye

2. Hasan Aydın Department of Pharmaceutical Toxicology Faculty of Pharmacy Adıyaman University 02200 Adıyaman Türkiye

3. Department of Medical Microbiology Faculty of Medicine Selçuk University Konya Türkiye

4. Department of Pharmaceutical Chemistry Faculty of Pharmacy Adıyaman University Adıyaman Türkiye

5. Virology Laboratory Pendik Veterinary Control Institute İstanbul Türkiye

6. Department of Parasitology Faculty of Veterinary Medicine Selçuk University Konya Türkiye

7. Department of Pharmaceutical Microbiology Faculty of Pharmacy Adıyaman University Adıyaman Türkiye

Abstract

AbstractGrowing number of deaths due to decreased effects of antibiotics has increased the need for new antimicrobial drugs. Studies on the pharmacological effect and toxicity of favipiravir, a new antiviral drug that was informally recommended by World Health Organization (WHO) for the treatment of Coronavirus Disease 2019 (COVID‐19) for a while, are limited and still ongoing. We first aimed to evaluate the antibacterial efficacy of favipiravir in silico. A second aim of the manuscript is to examine its antibacterial, antifungal, cytotoxic, antiviral and larvicidal effects in vitro. In this study, it was determined that favipiravir was effective in terms of in silico antibacterial, in vitro antibacterial, antifungal, cytotoxicity, antiviral and larvicidal activities. As a result, potential areas of use can be found in terms of activities under investigation.

Publisher

Wiley

Subject

General Chemistry

Reference54 articles.

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