Nickel‐Catalysed Decarboxylative Coupling Reactions – An Overview

Abstract

AbstractDecarboxylative cross‐coupling is a significant method in organic synthesis where inexpensive and stable carboxylic acids are used as substrates for the construction of C−C and C‐heteroatom bonds. First‐row 3d transition metals including nickel have recently been recognized as advantageous alternative to noble metals in transition metal catalysed decarboxylative couplings. In this review, Ni‐based catalysts for C−C (Csp3/Csp2/Csp) and C‐heteroatom (C−N, C−P, C−S, C−Si) cross‐couplings are summarized and most of the strategies find applications in the synthesis and modification of biologically important molecules. Importantly, Ni‐dual catalysis under photocatalytic and electrochemical conditions form the state of the art research in the field. This is the first review reported exclusively on Ni‐catalysed decarboxylative cross‐coupling and cover reports from 2009 to present.