In Vitro Cytocompatibility and Anti‐biofilm Properties of Electrodeposited Ternary‐Ion‐Doped Hydroxyapatite Coatings on Ti for Orthopaedic Applications

Author:

Bian Anqi1,Jia Fenghuan1,Wu Zongze2,Li Meiyu1,Yang Hao3,Huang Xiao4,Xie Lei5,Qiao Haixia1,Lin He6,Huang Yong15ORCID

Affiliation:

1. College of Lab Medicine Hebei North University Key Laboratory of Biomedical Materials of Zhangjiakou Zhangjiakou 075000 China

2. Department of Interventional Radiology Shenzhen People's Hospital (The Second Clinical Medical College Jinan University The First Affiliated Hospital Southern University of Science and Technology) Shenzhen 518020 China

3. Key Laboratory for Green Chemical Process of Ministry of Education Wuhan Institute of Technology Wuhan 430205 China

4. School of Physical Education Guangxi University of Science and Technology Liuzhou 545006 China

5. School of Medicine University of Electronic Science and Technology of China Chengdu 610054 China

6. School of Chemistry and Materials Science Ludong University Yantai 264025 China

Abstract

AbstractCurrently, there is a growing market for implant coatings that efficiently ward off bacterial infections while aiding in clinical osseointegration. Due to its potential to have a number of functions (including osteogenic activity and antibacterial activity) for bone implantation, the hydroxyapatite (HA) coating doped with multiple ions has drawn a lot of attention. In this study, innovative nanohydroxyapatite coatings containing simultaneous Sr2+, Mn2+, and Ag+ substitutions (MnSrAgHA) were devised and effectively electrodedeposited on pure titanium. That is, the antibacterial ability of MnSrAgHA was enhanced by Ag+, Sr2+ and Mn2+ not only can balance the potential cytotoxicity of Ag+, but also can improve the bone repair rate of composite materials. Some experimental (FE‐SEM, XPS and EDS, etc.) results about the characterization show that Sr2+, Mn2+ and Ag+ can uniformly combine into the HA lattice to form the SrMnAgHA coating. The MnSrAgHA coating surface was rather dense, with numerous needle‐like or flower cluster crystals, and the coating thickness is approximately 10 μm. Moreover, compared with other coatings (HA, AgHA and SrAgHA), the MnSrAgHA coating had a smaller roughness and higher contact angle. However, the contact angle of MnSrAgHA was still within the hydrophilic range. Staphylococcus aureus growth was inhibited by the MnSrAgHA coating, and the antibacterial rate was almost 100 %. The MnSrAgHA coating dramatically enhanced cell proliferation, adhesion, and differentiation abilities, according to in‐vitro cell culture studies. As expected, osteoblasts are not significantly cytotoxic by the MnSrAgHA coating. Due to its adaptability, the multi‐element co‐doped HA coating (MnSrAgHA) offers enormous clinical application potential in anti‐infective repair.

Publisher

Wiley

Subject

General Chemistry

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