Facile synthesis of chromeno fused imidazolidinone derivatives via copper‐catalyzed tandem O‐arylation/oxidative acylation protocol

Abstract

AbstractAn efficient copper‐catalyzed tandem reaction of 1,3‐dibenzylimidazolidine‐2,4‐diones with ortho halo‐benzaldehyde compounds toward chromeno fused imidazolidinone has been developed. This protocol proceeds via one‐pot sequential intramolecular O‐arylation (C−O bond formation) and oxidative acylation (C−C bond formation). The synthetic method has the advantages of easily available starting materials, good functional tolerance, and wide substrate scope, which make this protocol more sustainable and practical. Experimental outcomes demonstrate that radical pathway might be involved in these transformations.