I<sub>2</sub>/DMSO Mediated Direct Selenylation of Uracils with Diorganoyl Diselenides – A Simple Protocol to Access 5‐Selanyl‐Uracils-Reference-Cited by-同舟云学术

I₂/DMSO Mediated Direct Selenylation of Uracils with Diorganoyl Diselenides – A Simple Protocol to Access 5‐Selanyl‐Uracils

Published:2024-06-03 Issue:21 Volume:9 Page:
ISSN:2365-6549
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language:en
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Author:

Thedy Maria Eduarda C.¹,Gularte Mylena M.²,Azeredo Juliano B.²^ORCID,Braga Antonio L.¹^ORCID

Affiliation:

1. Departamento de Química Programa de Pós-graduação em Química Universidade Federal de Santa Catarina 88040-900 Florianópolis, SC Brazil

2. Núcleo de Pesquisa em Fármacos e Medicamentos Programa de Pós-graduação em Ciências Farmacêuticas Universidade Federal do Pampa 97501-970 Uruguaiana, RS Brazil

Abstract

AbstractThis study demonstrates a direct and regioselective selenylation protocol of unprotected uracils with diorganoyl diselenides using equivalent amount of DMSO as oxidant and minimum solvent, under catalysis by molecular iodine. This methodology tolerates a broad scope of functional groups to provide several 5‐organoseleno‐substituted uracil derivatives in good to excellent yields.

Funder

Conselho Nacional de Desenvolvimento Científico e Tecnológico

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

Publisher

Wiley

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