Unveiling the Potential of Surface Active Ionic Liquids Based Catanionic Vesicles for Tailored Delivery of Curcumin and its Enhanced Therapeutic Efficacy

Abstract

AbstractNano vehicles for drug delivery with stimuli‐responsive characteristics are gaining prominence due to their ability to enhance traditional drug delivery methods by minimizing side effects and improving drug efficacy. Among the various stimuli‐responsive systems, pH‐responsive drug delivery nano vehicles have garnered significant attention. Utilizing this pH variance, tailored drug delivery nano vehicles can release encapsulated drugs on demand. Here, we developed pH‐responsive catanionic vesicles to create customized drug delivery nano vehicles responsive to stimuli, particularly pH. we have designed catanionic vesicles through interacting two oppositely charged surface active ionic liquids (SAILs), i. e. cationic ‐methyl‐4‐(2‐(dodecyloxycarbonylmethyl)morpholin‐4‐ium bromide [C12EMorph][Br] with anionic Choline Oleate ([Ch][Ol]). The spherically shaped micellar aggregates of [C12EMorph][Br] are transformed into pH responsive vesicular nanoaggregates through judicious addition of [Ch][Ol]. The morphological transition was studied through various analytical techniques including DLS, FRET and SANS. We used these pH responsive vesicular nanoaggregates to load representative hydrophobic drug curcumin in order to enhance its solubility, efficacy and bioavailability. This innovative approach in designing pH‐responsive vesicular nanoaggregates using two biocompatible SAILs signifies a breakthrough in biomedical research, holding promise for advancements in drug delivery and therapeutic applications.