Microwave‐Assisted Copper‐Catalyzed Synthesis of Triazole‐linked 2‐Amino‐Pyrimidinone based Glycohybrids

Abstract

Abstract2‐Amino pyrimidines are vital molecules that exhibit diverse biological activities and serve as structural motifs in various pharmaceutical drugs. Four new series of triazole‐linked glycohybrids of 2‐amino‐pyrimidinones were designed and efficiently synthesized, using a microwave‐assisted method under click chemistry reaction conditions. The N‐propargyl‐2‐aminopyrimidinone and O‐propargyl‐2‐aminopyrimidine derivatives successfully underwent the click reactions with 1‐azido‐tetra‐O‐acetyl‐β‐D‐glucose, D‐galactose and D‐mannose. In this work, we reported the series of novel thirty‐three new triazole‐linked glycohybrid molecules with stereochemical diversity and diverse substitution patterns.