Affiliation:
1. School of Chemistry and Chemical Engineering Key laboratory of Material Chemistry for Energy Conversion and Storage (Huazhong University of Science and Technology) Ministry of Education Hubei Key Laboratory of Material Chemistry and Service Failure Huazhong University of Science and Technology Wuhan 430074 PR China
Abstract
AbstractTransition‐metal ions catalyzed intramolecular hydroarylation of aryl alkynoates to construct coumarin skeletons is merited for its step and atom‐economic advantages when compared with other methodologies. The challenge is that the electrophilic cyclization of this reaction requires the strong electrophilic capability of the catalyst, which makes this methodology was seldomly developed after its early explorations. Herein, we report a Lewis acid promoted Pd(II)‐catalyzed intramolecular hydroarylation to construct coumarin and its derivatives; the linkage of Lewis acid to the Pd(II) species through diacetate bridge improved its electrophilic capability, facilitating the hydroarylation reaction happening under the neutral conditions.
Funder
National Natural Science Foundation of China