Revolutionizing Indole Synthesis: A Microwave‐Powered Approach

Author:

Nigam Vaibhav1,Singh Surbhi1,Kasana Shivani1,Kumar Shivam1,Das Kurmi Balak2,Das Gupta Ghanshyam2,Patel Preeti1ORCID

Affiliation:

1. Department of Pharmaceutical Chemistry and Analysis ISF College of Pharmacy Moga, Punjab 142001 India

2. Department of Pharmaceutics ISF College of Pharmacy Moga, Punjab 142001 India

Abstract

AbstractTempted by the unique medicinal and biological potential of indole‐containing heterocycles, chemists, especially those specializing in heterocycle synthesis and drug discovery, are actively pursuing their efficient construction. This review spotlights the latest advancements in microwave‐assisted (M. W.) synthesis of diverse indole‐based heterocyclic compounds. We systematically categorize the reported methods based on the specific indole substitution patterns. This review concise the microwave assisted synthesis of indole based‐pyridine derivatives, indole based‐pyrimidine, indole based‐oxindole, spiro‐oxindole, Fischer indole Heck‐isomerization derivatives, functionalized indole, substituted indoles, indolyl quinoline, indole triazole and indolylnicotinonitriles derivatives. Ultimately, this review aims to provide organic and medicinal chemists with a concise yet informative guide to recent methodologies employing indole derivatives in the microwave‐powered synthesis of heterocycles.

Publisher

Wiley

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