Trifluoromethyltellurolation of Indole Derivatives with [Me<sub>4</sub>N][TeCF<sub>3</sub>] and NIS-Reference-Cited by-同舟云学术

Trifluoromethyltellurolation of Indole Derivatives with [Me₄N][TeCF₃] and NIS

Published:2023-07-13 Issue:26 Volume:8 Page:
ISSN:2365-6549
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language:en
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Author:

Dong Jing‐Yan¹,Wang Hao‐Nan¹,Zhang Cheng‐Pan¹²^ORCID

Affiliation:

1. School of Chemistry Chemical Engineering and Life Science Hubei Key Laboratory of Nanomedicine for Neurodegenerative Diseases Wuhan 430070 China Wuhan University of Technology

2. Key Laboratory of Organofluorine Chemistry Shanghai Institute of Organic Chemistry Chinese Academy of Sciences 345 Lingling Road Shanghai 200032 China

Abstract

AbstractMetal‐free trifluoromethyltellurolation of indoles with [Me4N][TeCF3] in the presence of NIS allowed a convenient synthesis of 3‐TeCF3‐substituted indole derivatives in good yields. The reaction proceeded smoothly under mild conditions and showed good functional group tolerance. It was noteworthy that [Me4N][TeCF3] had a distinct reaction profile for indole systems in comparison with [Me4N][SeCF3]. The trifluoromethyltellurolated products were unprecedented and decomposed rapidly even in the darkness and under a N2 atmosphere. This work represents the first metal‐free trifluoromethyltellurolation of indoles with the sensitive [Me4N][TeCF3] salt as TeCF3 reagent.

Funder

Wuhan University of Technology

Natural Science Foundation of Shandong Province

Publisher

Wiley

Subject

General Chemistry

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