A General Method for Elemental Sulfur Promoted Synthesis of Ortho‐Substituted Pyrrolo[1,2‐a]quinoxalin‐4‐yl Anilines

Abstract

AbstractSynthesis of heteroaryl ortho‐substituted anilines is hitherto challenging. Herein we report scope and limitation of method for annulation of 1‐(2‐nitroaryl)pyrroles and derivatives of 2‐aminobenzyl alcohol to afford ortho‐substituted pyrrolo[1,2‐a]quinoxalin‐4‐yl anilines. Reaction conditions contained elemental sulfur as promoter, while were tolerant of a wide range of aryl and heteroaryl amines. Our method would offer a feasible tactic to yield anilines steric bulk with ortho heterocyclic substituents.