Catalyst‐Free Defluoroalkylation of Trifluoromethylated Alkenes via Photoinduced Electron Donor‐Acceptor Complex
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Published:2023-06-06
Issue:22
Volume:8
Page:
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ISSN:2365-6549
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Container-title:ChemistrySelect
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language:en
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Short-container-title:ChemistrySelect
Author:
Gao Pan1,
Zhang Qingzheng1,
Li Yicheng1,
Cui Liping1,
Fan Xinting1,
Zhang Guodong1,
Chen Feng1ORCID
Affiliation:
1. School of Chemistry and Chemical Engineering Yangzhou University Siwangting Road 180 225002 Yangzhou China
Abstract
AbstractRadicals can be formed expeditiously through the direct irradiation of an electron donor‐acceptor (EDA) complex. Herein, we show a photocatalyst‐free strategy for gem‐difluoroalkenes synthesis realized by photo‐irradiation of the EDA complexes, which can be generated in situ between N‐alkylpyridinium salts and Hantzsch ester without any other additives. A wide variety of readily available alkylamines underwent deaminative defluoroalkylation to provide the corresponding gem‐difluoroalkenes. This reaction system exhibits high reactivity and good functional group tolerance and provides a practical and effective entry to a broad range of α‐alkyl‐substituted gem‐difluoroalkenes.
Funder
National Natural Science Foundation of China
China Postdoctoral Science Foundation
Natural Science Foundation of Jiangsu Province
Subject
General Chemistry