Affiliation:
1. School of Pharmaceutical Sciences Aichi Gakuin University 1-100 Kusumoto-cho Chikusa-ku Nagoya 464–8650 Japan
Abstract
AbstractNovel pyrido[1’,2’;2,3]imidazo[5,1‐a]isoquinolinium iodides independently substituted at their 5‐ and 6‐position were prepared from 5‐iodopyrido[1’,2’;2,3]imidazo[5,1‐a]isoquinolinium iodides using Suzuki‐Miyaura cross‐coupling reaction. The desired coupling products had cationic extended π‐conjugated skeletons and fluoresced strongly in the 420–460 nm region in methanol. In cell staining assay, the 5‐styryl‐substituted compounds, which showed lower fluorescence quantum yields in methanol, emitted high fluorescence in the intracellular environment and were specifically distributed to the endoplasmic reticulum.
Funder
Pharmaceutical Society of Japan