Cu‐Catalyzed Synthesis of Coumarin‐1,2,3‐Triazole Hybrids connected with Quinoline or Pyridine Framework**-Reference-Cited by-同舟云学术

Cu‐Catalyzed Synthesis of Coumarin‐1,2,3‐Triazole Hybrids connected with Quinoline or Pyridine Framework**

Published:2024-06-07 Issue:22 Volume:9 Page:
ISSN:2365-6549
Container-title:ChemistrySelect
language:en
Short-container-title:ChemistrySelect

Author:

Douka Matina D.¹,Sigala Ioanna M.²,Nikolakaki Eleni²,Prousis Kyriakos C.³,Hadjipavlou‐Litina Dimitra J.⁴,Litinas Konstantinos E.¹^ORCID

Affiliation:

1. Laboratory of Organic Chemistry, Chemistry Department Aristotle University of Thessaloniki Thessaloniki 54124 Greece

2. Laboratory of Biohemistry Chemistry Department Aristotle University of Thessaloniki Thessaloniki 54124 Greece

3. National Hellenic Research Foundation Institute of Chemical Biology Athens 11653 Greece

4. Department of Pharmaceutical Chemistry School of Pharmacy, Faculty of Health Sciences Aristotle University of Thessaloniki Thessaloniki 54124 Greece

Abstract

AbstractCoumarin‐1,2,3‐triazole hybrids connected to quinoline or pyridine framework have been synthesized in good to excellent yield by the 1,3‐dipolar azide alkyne cycloaddition reaction (CuACC) of 4‐azidocoumarin with propargyl quinoline or propargyl pyridine derivatives in the presence of CuSO4.5H2O or CuI as catalyst. Similar reaction of 4‐azidocoumarin or tetrazolo[1,5‐a]pyridine with 4‐propargyloxycoumarin and 4‐propargylaminocoumarin resulted in the synthesis of the corresponding coumarin‐1,2,3‐triazole hybrids. Some preliminary screening test for some biological activities of new compounds have been performed.

Publisher

Wiley

Reference142 articles.

2. Natural and Synthetic Coumarin Derivatives with Anti-Inflammatory / Antioxidant Activities

3. Coumarin heterocyclic derivatives: chemical synthesis and biological activity

4. Coumarin: A Natural, Privileged and Versatile Scaffold for Bioactive Compounds