One‐Pot Three‐Component Synthesis of Biologically Promising Indenoquinoxaline Fused Spiroheterocycles Starting from 11H‐indeno[1,2‐b]quinoxalin‐11‐ones

Abstract

AbstractHeterocycles are very common in many naturally occurring bioactive compounds as well as in the commercially available drug molecules. Very recently spiroheterocycles have gained considerable attention due to their wide range of pharmacological applicability. Among many others, 11H‐indeno[1,2‐b]quinoxalin‐11‐one in recent time have gained significant attention as an important building block to prepare structurally diverse biologically promising spiroheterocycles under various reaction conditions. On the other hand, it was found that one‐pot three‐component reaction strategy plays an important role in the preparation of spiroheterocycles starting from 11H‐indeno[1,2‐b]quinoxalin‐11‐one as it has many advantages including high atom economy, operational simplicity, easy workup procedures, reduction of byproducts, energy and reaction step efficiency etc. In this review, we have discussed all the recent developments related to the one‐pot three‐component synthesis of biologically promising indenoquinoxaline fused spiroheterocycles starting from 11H‐indeno[1,2‐b]quinoxalin‐11‐ones under diverse reaction conditions.