Affiliation:
1. Department of Medicinal Chemistry School of Pharmacy Guilan University of Medical Sciences Rasht Iran
2. Department of Chemistry Islamic Azad University Rasht Branch Rasht Iran
Abstract
AbstractIn this work, twenty new polysubstituted propargylamine analogs were produced in good to excellent yields via one‐step reaction of alkynes, aromatic aldehydes, and cyclic secondary amines using CuCl2 in DMF under ultrasound irradiation at 80 °C. Twelve compounds having both quinazoline building block and propargylamine scaffolds were synthesized.